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Peptides/Peptides International/1000µg/NRV-215-1000µg

Peptides/Peptides International/1000µg/NRV-215-1000µg
  • Peptides/Peptides International/1000µg/NRV-215-1000µg
商品介绍
  • Product Code: NRV-215
  • Human norovirus is classified into two groups, group 1 & group 2. Norwalk virus is the species which belongs to group 1 and was discovered in 1968 at Ohio. Norovirus is a familiar virus which causes human gastroenteritis with the following symptoms: vomiting, diarrhea and sickness. A CDC report revealed that there are 19-21 million Americans infected by Nororvirus annually with 800 deaths, 1 in 15 people with infection. Around the world, this virus affects about 267 million people and causes over 200,000 deaths each year; these losses are mostly in less developed countries and in the very young, elderly and immuno-suppressed population, though, most cases are self-limited with a full recovery within just a few days. Norovirus is extremely contagious and can spread from human to human through infected food, water or contaminated surfaces. The outbreaks usually occur from November-April, with the peak in January. Norovirus is a positive sense RNA virus with 7.5 kb nucleotides, encoding a major structural protein VP1 with 50-55kDa. The full length ofVP1 capsid comprises the internal N-terminal, Hinge, shell (S) and protruding (P) domains. P domain from 225 to 520 forms P1- P2-P1 structure. Moreover, P domain has a receptor binding region which recognizes human histo-blood group antigens (HBGAs). P domain expressed in bacteria can spontaneously form a P dime as well as a P particle aggregated by 12 P dimmers. P particle displays an increased binding activity to HBGAs higher than virus-like particle (VLP) formed by the full-length capsid. For norovirus vaccine development, we consider P domain as a good candidate.

    The Recombinant Norovirus Group-1 Capsid P-Domain, is E. coli derived, and the Norwalk strain contains amino acids from 225-520 having a molecular weight of 30kDa. The protein is fused to a 6xHis tag at N-terminal and purified by chromatography techniques.

    P-domain (225-520 a.a.) forms P1- P2-P1 structure. P-domain has a receptor binding region to recognize human histo-blood group antigens (HBGAs). P-domain expressed in bacteria can spontaneously form a P dime and a P particle aggregated by 12 P dimmers. P-particle displays an enhanced binding activity to HBGAs higher than virus-like particle (VLP) formed by the full length capsid.

    Physical Appearance: Sterile filtered clear solution.

    Formulation: Phosphate buffer and 10 mM K2CO3.

    Stability: Although the Recombinant Norovirus Group-1 P-Domain is stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.

  • Origin: Escherichia coli
  • Storage Conditions: -20 ℃
  • Purity: > 95% pure as determined by 12% PAGE (coomassie staining)
  • Molecular Weight: 30kDa

Delivery Details: All quantities are subject to availability. Please allow 7-10 days for delivery.

品牌介绍

Peptides International由已故的阿诺教授创立于1983年,目的是为了满足多肽合成领域的优质产品和服务的需要。 30年后,该公司已成为全世界公认的高纯度,优质的自定义肽供应商。Peptides International仍然是一个私人公司,为Jacqulyn Spatola所有。

如今,在Peptides International实验室,该公司有一个活跃的研究和发展计划,完善其固相树脂,氨基酸衍生物,肽类,及相关产品的生产。它也支持发展的新产品,如CLEAR-OX™聚合物载体氧化剂和有针对性的组合肽库。纵观其历史,Peptides International一直与处于世界领先地位的复杂多肽合成研究所保持着密切的联系。该公司提供全面优质及专业化的产品组合。



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作为世界上第一家成立的专业多肽合成公司,Mimotopes Peptides一直领导全球合成多肽及多肽文库市场,其多肽文库一直以高质量,专业化,稳定性与可靠性稳踞市场占有率第一的位置。作为一家世界领先的生物技术公司,它不仅提供高质量的合成多肽,多肽文库,还提供各种氨基酸,合成肽试剂及周边产品,抗体制备以及免疫学服务。其客户从小微企业、小实验室至各个大学、大企业遍布全球。产品覆盖从单一的免疫学鉴定与检验到大规模药物开发,药物筛选,其领域涉及生物医学,生物制药,基础生命科学研究等方面。
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